Medications for the Treatment of Type 2 Diabetes
2008-02-04 09:08:00
Diabetes is a major health problem in the United States and its incidence is rising. The term echogenic disease, a disease with environmental and genetic factors, certainly describes type 2 diabetes mellitus. The alarming increase of type 2 diabetes is certainly linked to the environmental factors of a sedentary lifestyle and increasing rates of obesity, as well as family history and genetics. Prior to 1994, the treatments for type 2 diabetes were limited to the sulfonylurea (SU) class of oral hypoglycemic agents, injectable insulin, and diet and exercise. Four new classes and at least 8 new oral agents have become available for the treatment of type 2 diabetes since 1994. In addition, several new types of insulin have become available, including 2 short-acting agents and 1 basal/long-acti
Read more: Treatment
, Diabetes
Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions.
2007-09-01 10:12:00
Herbal medicinals are being used by an increasing number of patients who typically do not advise their clinicians of concomitant use. Known or potential drug-herb interactions
exist and should be screened for. If used beyond 8 weeks, Echinacea could cause hepatotoxicity and therefore should not be used with other known hepatoxic drugs, such as anabolic steroids, amiodarone, methotrexate, and ketoconazole.However, Echinacea lacks the 1,2 saturated necrine ring associated with hepatoxicity of pyrrolizidine alkaloids. Nonsteroidal anti-inflammatory drugs may negate the usefulness of feverfew in the treatment of migraine headaches. Feverfew, garlic, Ginkgo, ginger, and ginseng may alter bleeding time and should not be used concomitantly with warfarin sodium. Additionally, ginseng may cause hea
Read more: Herbal
, clinical
Benfotiamine Prevents Postprandial Symptoms in Diabetes
2006-04-17 08:06:00
NEW YORK (Reuters Health) Sept 22 - Benfotiamine prevents the endothelial dysfunction and oxidative stress that follow a meal rich in advanced glycation end (AGE) products in type 2 diabetics, according to a report in the September issue of Diabetes
Care."Benfotiamine was used for decades as a treatment of diabetic neuropathy, without any exact knowledge of the beneficial mechanism," Dr. Alin Stirban from Ruhr-University, Bochum, Germany told Reuters Health. "Our data bring benzoctamine from the relatively restricted field of diabetic neuropathy into the much larger field of vascular function and prove in humans effects previously postulated."Dr. Stirban and colleagues investigated the effects of a real-life, cooked, AGE-rich meal on endothelial function and oxidative stress with or withou
Effect of Diabecon on sugar-induced lens opacity in organ culture: mechanism of action.
2005-11-22 09:25:00
Cataract is the leading cause of blindness worldwide. Apart from ageing, diabetes has been considered to be one of the major risk factors of cataract. The high sugar levels in diabetes may cause tissue disruption and intumescences by osmotic changes induced via aldose reductase (AR) mediated polyol pathway.Therefore, agents that can inhibit AR and prevent sorbitol accumulation may be helpful to combat sugar-induced cataract. In the present study, AR inhibitory activity of Diabecon (an herbal drug used for diabetes) was studied together with its effect against sugar-induced lens opacity in organ
culture
. Diabecon aqueous extract (DAE) showed potential inhibitory activity with an IC50 value of 10 microg/ml against rat lens AR. Incubation of goat lens with supraphysiological concentrations of
Read more: mechanism
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