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Rimonabant accepted for filing by the FDA 2007-08-10 06:18:07 Rimonabant accepted for filing by the FDA
Sanofi-aventis announced today that the United States Food and Drug Administration (FDA) has accepted for filing the company’s New Drug Application (NDA) for rimonabant, the first agent in a new therapeutic class known as selective cannabinoid type 1 (CB1) blockers.
Rimonabant, discovered and developed by sanofi-aventis, is thought to represent a new approach for the comprehensive management of cardiovascular risk factors. The compound has been studied to date in over 6,500 overweight and obese adults for up to 2 years.
Despite therapeutic advances in recent decades, cardiovascular disease remains the leading cause of mortality worldwide. Current treatments generally target risk factors individually, rather than providing a comprehensive management approach to such cardiovascular risks as dyslipidemia, abdominal obesity and insulin resistance, which comprise the metabolic syndrome.
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Of some 41,000 patients treated with rimonabant since it was launched in the U.K. in June 2006, 364 “psychiatric reactions have been reported,” the Department of Health’s Medicines and Healthcare Products Regulatory Agency (MHRA) said on July 19th.
“Amongst these, there have been 48 reports of depression, 16 reports of suicidal thoughts and one report of self-injury,” the regulatory agency said.
The MHRA said evidence suggested one person in 10 taking Acomplia may develop psychiatric side effects, and “approximately one patient in every 100 may experience suicidal thoughts.”
The MHRA advised: “If you start to experience symptoms of depression while taking Acomplia, or if you are currently being treated with antidepressants
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Acomplia, New Study Finds Diet Drug Acomplia May Help Reduce Liver Damage 2007-08-09 09:36:46
A new animal study on rimonabant (Acomplia / Zimulti) has identified yet one more possible health benefit for this controversial diet drug: it appears to reduce obesity-related liver damage that can lead to cirhossis of the liver.
A team of researchers led by Mohammed Bensaid of Sanofi-Aventis, the company that has developed rimonabant, reported on these latest developments in the July 2007 issue of Hepatology, the official journal of the American Association for the Study
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Male obese rats were given rimonabant orally daily for 8 weeks and had their food intake monitored; control animals received the same amount of food as those receiving rimonabant.
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A new anti-obesity pill that has been shown to not only help lose weight and quit smoking could also be effective in helping people stop drug and alcohol addiction, scientists claim. Acomplia, or rimonabant, is an experimental drug developed by the French pharmaceutical firm Sanofi-Aventis primarily as a diet pill, but the drug works differently that most diet pills in that it blocks the brain’s reward system.
It works by blocking the connection between a pleasure-seeking activity, like smoking or overeating, and the reward “feeling” it causes in the brain. The human body contains endocannabinoids, marijuana-like substances that can stimulate the brain’s reward system.
Acomplia blocks the effect of the natural endocannabinoids by keeping them from attaching to the brain cells they usually stimulate, scientists say.
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Acomplia Side Effects 2007-08-07 11:23:11 Background
Rimonabant (brand name Acomplia) has been pitched as the blockbuster weight loss drug of the decade. The company manufacturing the drug, Sanofi-Aventis believes that sales will reach $5.2 billion per year by 2010. That is a staggering amount of money.
Investors are getting swept up in the buzz, (rimonabant online),and desperate consumers are falling over themselves to get an opportunity to try the drug. However it is currently before the FDA awaiting approval - which some believe may come during early/mid 2006. Acomplia blocks cannabinoid (CB) receptors in the brain. The CB receptors are believed to play a role in controlling food consumption and dependence / habituation. People often refer to the cannabis-induced “munchies” or hunger pangs. Acomplia attempts to do the opposite.
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The drug, rimonabant, works by blocking the circuits in the brain that control the urge to eat and smoke.
Obesity and smoking have become two of the world’s biggest killers, and are being targeted for action in the UK.
The makers, French firm Sanofi-Synthelabo, hope to market rimonabant diet pill drug next year.
We think this might be the ideal compound for people who are overweight and smoke.
Dr Robert Anthenelli
In one trial the drug helped people to shed an average of 9kg (20lbs) in a year.
And in a second, it was found to double the chances of smokers successfully quitting - at least in the short term.
Dr Robert Anthenelli, of the University of Cincinnati, who directed the smoking study, said: “We think this might be th
Rimonabant still on the market! 2007-08-07 11:07:37 Suicide risk fears over diet pill
The drug works by reducing appetite
A weight loss drug used by thousands of Britons has been rejected by US safety officials because of an increased risk of suicide.
Rimonabant, launched in the UK last summer, has been shown to aid weight loss by reducing appetite.
But a committee advising the US Food and Drug Administration (FDA) voted to ban the pill, saying the manufacturers had failed to show it was safe.
European regulators will review the drug’s safety at an upcoming meeting.
Around 37,000 Britons have been prescribed rimonabant which can help users lose up to 10% of their body weight.
Rimonabant has a role, it should be used with care but directed towards the right patient it can be effective and safe.
Dr Ian Campbell, Weight Concern
The drug is currently recommended for obese patients with a risk of developing diabetes or cardiovascular disease.
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Rimonabant Precautions online 2007-08-06 20:21:18 Rimonabant Precautions
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The active substance is Rimonabant. Each film-coated tablet of Rimonabant (Acomplia, Zimulti) contains 20mg of rimonabant. The other ingredients are: Tablet Core: maize starch, lactose monohydrate, povidone K30 (E1201), croscarmellose sodium (E468), sodium laurilsulfate (E487), miceocrystalline cellulose (E 460), magnesium stearate.
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It is advisable to stick to the prescribed Rimonabant dosage to attain the expected results. Pregnant women and breast-feeding mothers should avoid consumption of rimonabant, acomplia, or zimulti. Kindly inform your doctor about your medical history and any medication that you are taking, in order to avoid any contraindications of rimonabant diet pills .
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Dr. CELESTE ROBB-NICHOLSON : Scientists are studying factors that influence how full we feel and how fast we burn calories. Prescription weight-loss drugs–which include phentermine (sold as Adipex-P and other brand names), sibutramine (Meridia) and orlistat (Xenical)–can temporarily manipulate some of these factors. Another new drug, acomplia without prescription, which blocks an appetite receptor in the brain, is awaiting approval from the Food and Drug Administration. (And Xenical may be available over the counter later this year.) The National Institutes of Health recommends that weight-loss drugs be given only to people with a body-mass index (BMI) over 29–or 27, if the patient has weight-related problems like type 2 diabetes, high blood pressure or arthritis. They should be taken in conjunction with lifestyle changes and they do have side effects, so check with your doctor. Those who lose w
Cheap Rimonabant for sale 2007-08-12 16:18:01 Rimonabant for sale, an investigational drug that is a cannabinoid-1 receptor blocker, promoted modest but sustained decreases in weight and waist circumference when combined with a low-calorie diet, reported Dr. F. Xavier Pi-Sunyer of the Obesity Research Center at St. Luke’s-Roosevelt Hospital, New York, and associates.
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We may at last have the long-awaited anti-fat wonder drug. Sanofi-Aventis’s Acomplia (rimonabant) helps people to lose weight, stop smoking and, unexpectedly, increase their good cholesterol levels.
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Millions of Americans take popular drugs to lose weight, but the long-term risks and benefits of these medications aren’t known, two Canadian researchers contend. Drs. Raj Padwal and Sumit Majumdar, of the University of Alberta, said long-term studies are needed to determine whether losing weight on drugs such as sibutramine (Meridia), orlistat (Xenical) and rimonabant canada (Ac Read more:Cheap
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Rimonabant is currently being sold in the United Kingdom by Sanofi-Aventis and in Denmark by Sanofi-Synthelabo under the trade name Acomplia (which is the name …
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A few days after the latest clinical results with rimonabant were published in the Feb. 15 issue of the Journal of the American Medical Association, the Food and Drug Administration declined to approve this widely anticipated new drug, according to the February 18 issue of the Wall Street Journal. Rimonabant (Sanofi-Aventis) has been causing excitement among physicians and patients alike during the past several years. Over that time, randomized clinical trials have shown that the drug can help with both sustainable weight loss and with smoking cessation.
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Acomplia (rimonabant) has been licensed in the UK only for obesity treatment and not for smoking cessation. Although during clinical studies the drug clearly demonstrated a reduced craving for nicotine in patients the drug has only at the moment been approved treatment of obesity. As this is a prescription medication we strongly advise consulting your doctor or a certified physician. Our service is not/should not be considered as an alternative to the treatment advice your doctor can provide.
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Rimonabant is the first drug designed to affect your endocannabinoid system, which influences energy balance, fat storage, cholesterol, and blood-sugar levels. In 2005, U.S. and European researchers reported 2-year results from rimonabant studies that are nothing short of astonishing.
In the American trial, 3,040 volunteers were put on a reduced-calorie diet. Some were given the drug; others, a placebo. After 2 years, the waistlines of volunteers on rimonabant were more than 3 inches smaller (compared with 1.5 inches in the placebo group); 30 percent lost more than a tenth of their body weight (compared with 16 percent with the others). Most surprising, the drug raised HDL, or good, cholesterol by a whopping 25 percent on average. “And
Rimonabant Shows Promise for Prevention of Type 2 Diabetes 2007-08-22 13:28:51 Rimonabant, a selective CB1 endocannabinoid receptor antagonist, may have potential in the prevention of type 2 diabetes, according to a study presented here at the 41st annual meeting of the European Association for the Study of Diabetes
.Julio Rosenstock, MD, from the Dallas Diabetes Center in Texas, presented one-year data from the rimonabant prediabetes subgroup of patients who were enrolled in the RIO-Lipids, RIO-Europe, and RIO-North America phase 3 studies. These studies were multicenter, randomized, double-blind, placebo-controlled trials that asssessed 5 or 20 mg of rimonabant in overweight/obese patients. The primary end point of these pivotal studies was weight loss, and secondary end points included waist circumference, glycemic control, and lipid parameters.
For the prediabetes subgroup analysis of 1,290 subjects, prediabetes was defined as impaired fasting glucose (100-125 mg/dL).
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Acomplia Rimonabant diet pill 2007-09-20 11:34:27 Rimonabant for Obesity
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Rimonabant Acomplia weight loss pill 2007-09-09 10:12:12 What Is Rimonabant?
A single pill Rimonabant has been found to stop food craving enough to help people lose weight, and could also help curb other unhealthy urges. Named Rimonabant Acomplia the drug in one study helped people who were overweight drop an average of 20 pounds and very useful for the patients who suffer from obesity. Rimonabant Acomplia is made by French firm Sanofi-Synthelabo and the company says it is available now in Europe. Acomplia contains the active ingredient Rimonabant. It is a selective CB1 endocannabinoid receptor antagonist.
Clinical data on Acomplia has shown that nearly of the one third of patients treated with 20 milligrams of Acomplia over the full two years lost an excess of 10 per cent of their initial body weight. More than 62 per cent of 20 mg Acomplia patients shed at least 5 per cent of body weight. Waist circumference at two years was reduced by 3.1 inches (8 cm) in the 20 mg Acomplia group, by 1.9 inches (4.9 cm) in a 5 mg Acomplia grou
Rimonabant, one pill that helps you to lose weight fast 2007-09-02 23:53:49 We all know pill popping isn’t the answer when it comes to losing weight and keeping if off. But clinical trials with a new anti-obesity drug look promising. The drug, called rimonabant, was developed after scientists noticed that cannabis smokers often had increased appetites and frequently experienced the ‘munchies’.
They worked on the idea that if substances from cannabis called cannabinoids stimulated appetite, blocking the cannabinoid receptors in the brain might reduce appetite.
Furthermore, blocking these receptors might also help people to give up smoking as these receptors not only appear to be involved in controlling food intake, but also have a role to play in tobacco dependence.
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Buy Acomplia Rimonabant pills, order diet pills acomplia rimonabant online 2007-09-02 23:49:31 Beware of Generic Acomplia Rimonabant Zimulti available in Market now
However there are now websites offering generic Acomplia to US and UK customers. In nearly all cases the medication is coming from developing countries such as India and China. The manufacturers of these generics are not covered by any medical authority or body and as a result the ingredients in the drug may differ from what they claim which can lead to serious health risks.
We Strictly offer Branded Acomplia Rimonabant which is manufactured by Sanofi-Aventis.
Rimonabant is sold under the brand name Acomplia in Europe and by the brand name Zimulti in USA. EU Union has approved Acomplia for weight loss treatment but Zimulti is still waiting for the approval in USA from FDA.
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Best Obesity solution - Rimonabant-acomplia 2007-10-17 20:24:00 Obesity was a rare occurrence, a few years back. It is no more so. At one time people identified obesity as the cause for some underlying physical disorder or mental disability, so they sought to control excess weigh. But later obesity by and large came to be viewed and specified as being the symbol of good health or good personality. Remarks like “how healthy he looks!” “What a personality he has!” are not uncommon. Even in families where no one is obese, we find children who are either obese from childhood or become obese a few years later.
Obesity also affects youngsters who have reached marriageable age. They find difficulty in getting married as most suitors’ dislike to get saddled with an obese partner especially girls. An overweight male is viewed to be a majestic personality who commands respect and even fear in some cases. However in case of females they are ridiculed, rejected in marriage alliances and even despised in some cases. This is one of
Diet Drug Acomplia Reduces Fats very much 2007-10-16 17:18:00 A Study found that Diet Drug Acomplia Reduces Fats very much
In a multi-center study in Japan Diet drug Acomplia (rimonabant, online is the way that you can buy it) was found to reduce very much human visceral fat — the dangerous abdominal fat –,that was announced of Sanofi-Aventis on Sept. 18th.A report on the study was presented at
this year meeting of the European Association for the Study of Diabetes and it talks about the first direct evidence of the way that rimonabant (Acomplia / Zimulti which can be found online) is decreasing the metabolically active fat.That refeares to the fat which surrounds some vital organ as the pancreas and liver.
Researchers reported that the visceral fat area was more reduced in the study, in 526 obese Japanese participants that were taking the customary 20 mg rimonabant dosage (-40.6cm2) than for those taking a placebo (-20.3cm2).
In the human body exist a couple of adipose tissue, which are cha
Vernalis Said That The New Diet Drug Similar to Rimonabant Is Promising 2007-10-26 13:12:14 The UK company, Vernalis, announced on Sept. 13th ,that they are developing a new diet drug that it’s similar to Rimonabant, V24343, and it had produced “outstanding weight loss” in persons in two small phase I at the clinical trials.As an exemple one patient lost 24 pounds in a couple of weeks.
The Vernalis medication, just as Rimonabant, is a CB-1 receptor antagonist which is acting by targeting the CB-1 receptor located in the brain and blocking a person’s desire to eat. Vernalis said that their results on the weight loss produced by the new drugits drug are compareble with results for rimonabant.
Average weight loss after 15 days was 1 pound for the overweight and mildly obese patients given a placebo, 5 pounds for those on a 5 mg dose of V24343 and 10 pounds for those on a 100 mg dose.
But Vernalis,the producer of the new drug ,rival of Rimonabant, said results for V24343 from its early tests showed “a reduced intensity for neurol
Obesity solution 2007-10-26 11:18:21 A closer look on Rimonabant for Obesity solution
At the latest European Society of Cardiology Congress, new reports about how effective rimonabant is in treating obesity. Rimonabant, an investigational drug produced by Sanofi-Aventis, it’s very effective in helping patients to lose weight and quit smoking. The newest trials with this drug are very promising.
In their latest trial, 1507 overweight and obese persons were treated by receiveing either placebo or one of two doses of rimonabant (5 mg or 20 mg per day.). People taking 20 mg rimonabant had loss weigh very much,but in the same time their lipid profiles improved, compared to people who were on placebo. (Those taking 5 mg still loss more weight than placebo patients, but the weight loss wasn’t that big .) Plus all that, waist measurements improved a lot in persons treated with rimonabant.
In those taking the 20 mg dose, almost 42% of patients lost 11% of their baseline body weight, HDL cholesterol (the