Genetics

Germany. Max Planck Institute. Four years full-time Postdoctoral positions in the division of Neurosciences, Max Planck Institute for Medical Research. The work will be in a project entitled “Developmental Genetics of Nervous Systems“. Expected candidates should hold PhD in Biological Science, strong background in neurobiology and neuroanatomy and experience in confocal microscopy and molecular

ICIN - KNAW At the ICIN there's a vacancy open for a PhD Molecular biology, cell biology or genetics L. de Windt(Utrecht), 38 hours per weekICIN - KNAWJob description Function title: PhDThe successful applicant will explore the biological and pathophysiolgical role of selected microRNAs in genetically engineered mice and in vitor model systems.Requirements Required education/skills:We seek a PhD trainee who has received training in the field of molecular biology, cell biology or genetics for this project.Job type: Research / AdvisingWorkfield(s):- Teaching & Research(Scientific discipline: Health)Organization ICIN - KNAWThe Interuniversity Cardiology Institute (ICIN) is a leading institute in research into cardiovascular diseases. ICIN is an institute of the Royal D

Daniel Kevles, a professor at Yale University, warns that dramatic advances in genetic science have "revived some of the old issues" surrounding the eugenics movement that flourished in the United States and Europe during the early part of the 20th century.   [ ... ]   Kevles said many people are stunned to learn that "liberal, democratic Sweden" sterilized approximately 60,000 people between the 1930s and the 1970s. Between the start of the 20th century and World War II, two dozen American states passed laws authorizing the forced sterilization of "the feeble minded" and others labeled as genetically flawed. In 1927, the U.S. Supreme Court voted 8-1 to uphold Virginia's eugenics law, with the majority opinion written by Oliver Wendell Holmes Jr. And, according to Kevl

Genetics facts• Ova and sperm each contain 23 chromosomes.• A fertilized cell has 46 chromosomes.• Each chromosome contains DNA.• DNA contains genes.• A person receives one set of chromosomes and genes from each parent.• More powerful gene is dominant.• Less influential gene is recessive.Types of genetic disorders• Single-gene — inherited in clearly identifiable patterns. Two important inheritance patterns are:–autosomal dominant–autosomal recessive.• Chromosomal — deviations in either the structure or the number of chromosomes involving the loss, addition, rearrangement, or exchange of genes.• Multifactoral — caused by genetic andenvironmental factors.How genetic disorders develop• Cleft lip and cleft palate — arise from interaction of several genes that

“Let’s play that if you finish your dinner first then you win and if I finish my dinner first then I win,” The Mayor said to me.“Okay,” I said smugly, knowing I would win. [Look kid, I’ve been inhaling my food since the day you were born!]I tried to eat slowly to let him win, but there is no pace as slow as a toddler eating and, as I knew I would, I finished first.When I showed The Mayor my clean plate he instantly went from sunny to thunderstorms and yelled,“YOU CAN NEVER PLAY THIS GAME WITH ME EVER EVER AGAIN!”“You don’t like to lose do you Mayor?” I said calmly.“NO! NO! NO!” he yelled.K smirked and made a face that mocked me.I don’t like to lose either. Not. At. all.[K and I had to give up playing the game formerly known as Scrabble (now known as DIVORCE) be

Product Description Significant progress has been made in understanding the pathogenesis of many allergic disorders. In spite of the tremendous complexity, dramatic progress in the past few years has led to an improved understanding of the genetic contributions to allergic and immunoregulatory disorders. This issue is divided into four parts: reviews of positional cloned genes from family

Well, it's been 6 months since Genetics kicked me in the nuts and made it completely obvious to me that aiden_freeman is undoubtably 'of my loins'So, now at 18 months...it's time to take a look at some of the other genes. I've pulled out the old photo of me and this time added in one of shimmeringjemmy

Hi, below please find an advert for an open PhD student position in my lab. I am looking for a motivated, technically skilled and socially competent student to join the lab on a maize-symbiosis diversity project. Please contact me electronically or see my at the maize meeting in Washington UTA PhD thesis GENETIC TRAITS DETERMINING MYCORRHIZAL RESPONSIVENESS IN MAIZE The mutually beneficial

Here's Dova in her brand new Barbie glasses. She failed her last preschool eye exam in one eye, so we took her to the eye doctor to find out that she has astigmatism in her left eye, exactly like her brother and her mother. Is it possible that genetics are so specific that astigmatism in one eye can be passed on to exactly the same eye in both children? Apparently it is in our family. Unlike the rest of the family however, she is slightly far-sighted where we are all near-sighted. Brother Adam and dad Doug are slightly near-sighted and I am hopelessly near-sighted, although my vision has improved ever so slightly in my old age (check the links for all our glasses). I started wearing glasses at 7, not as early as these kids at 5 and 4, but I think early screening has improved. My visio

Genetic tests exist for Celiac disease and are highly accurate for determining the risk of the disease. When a complete genetic panel is performed the possibility that someone having or ever getting Celiac disease can be determined to an extremely high degree of certainty. Unfortunately, some tests are misleading because they do not include a portion of the genetic pattern that may be present that can predispose to the disease yet the report may imply absence of increased risk. Some tests can be done without a doctor’s order. Insurance coverage for the tests is highly variable. A couple of laboratories can run the tests on samples obtained from a mouth swab that is painless and well accepted by children. Genetic testing can be done at any age whereas blood tests for Celiac disease are no

The miraculous substance, DNA, which contains all the genetic instructions, is rapidly becoming a key to modern medicine. By focusing on the diaphanous and extraordinarily long filaments of DNA, scientists are finding the root causes of dozens of previously mysterious diseases.Recently, scientists have made spectacular progress against a fatal genetic disease, cystic fibrosis, affecting children. The scientists have succeeded in correcting the gene defect inside living human cells by inserting healthy genes into these cells in a laboratory dish.The Progress in the field of medical genetics is gaining momentum. Scientists are constantly trying to work on effective ways to cure genetic disorders.The National Institute of Science and Media keeps you informed on the recent advances in biotechn

The miraculous substance, DNA, which contains all the genetic instructions, is rapidly becoming a key to modern medicine. By focusing on the diaphanous and extraordinarily long filaments of DNA, scientists are finding the root causes of dozens of previously mysterious diseases.Recently, scientists have made spectacular progress against a fatal genetic disease, cystic fibrosis, affecting children. The scientists have succeeded in correcting the gene defect inside living human cells by inserting healthy genes into these cells in a laboratory dish.The Progress in the field of medical genetics is gaining momentum. Scientists are constantly trying to work on effective ways to cure genetic disorders.The National Institute of Science and Media keeps you informed on the recent advances in biotechn

A study published earlier this year in the American Journal of Medical Genetics suggests that lymphoblast gene expression may be used to identify biomarkers for panic disorder. Researchers at the University of Iowa evaluated gene expression profiles in lymphoblasts (immature white blood cells) cultured from patients with and without panic disorder and found specific disorder- and sex-related differences [1]. A blood test for panic disorder and other mental health conditions based on the study results is being developed. However, a commercial diagnostic test may be premature as the study results are far from conclusive. Panic attacks and panic disorder Panic attacks are episodes of acute, intense anxiety, characterized by a variety of physical symptoms that may include numbness in the hands and feet, shortness of breath, chest pain, heart palipitations, dizziness and a feeling of loss of control or dying. The onset of a panic attack is sudden and may have no obvious trigger. A panic att

Three papers from UC Davis have appeared on the PLoS journals in the past few days that bring together population genetics and genomic sequencing to address questions of importance to evolutionary biology. Their discussions of divergence in coding versus non-coding, and adaptive versus neutral shifts, are what caught my eye. Collectively, they’re three very densely packed studies, providing a fountain of info that only bioinformatics can process. (more…)

Applications are invited for suitably qualified graduates who have a good honours degree in Microbiology or a related subject (e.g. Biochemistry, Genetics, Biotechnology, Molecular Biology, etc.) to...

We’ve talked previously about the health benefits of coffee and the antioxidant compounds responsible for it’s bitterness. To add to the “perks” of coffee consumption, a recent report in the Journal of Cancer Epidemiology Biomarkers & Prevention suggests that caffeine protects against breast cancer in women that have a BRCA1 gene mutation. What is BRCA1? The acronym stands for breast cancer 1, early onset. The BRCA1 gene encodes a protein that plays a role in maintaining genomic stability and acts as a tumor suppressor. Approximately 5%-10% of breast cancer and ovarian cancer is hereditary and 30%-50% of these are due to DNA mutations in the genes BRCA1 and BRCA2 [1]. Women age 35-40 that carry the BRCA1 mutation are particularly susceptible with a risk between 45%-60% of developing breast cancer [1]. The absolute risk of cancer by age 70 is reported to be between 45% and 87% [2-3]. The authors of the report had previously evaluated the association between c

We recently talked about financially changing your family tree as financial motivation, but for those of us needed some more convincing here is evidence that our decisions about money go much deeper than just dollars and cents. Our choices are crucially importance to our children and this offers early stage evidence that our choices can cover over ‘bad’ genetics. The researchers “studied 109 children who had been removed from their parents’ care due to reports of abuse or neglect and 87 control children with no reports of abuse or maltreatment.” The children also had two gene polymorphisms that put them at a greater risk for depression. The researchers also assessed each child’s support system and assigned each one a score for their support system quality . I picked up three import things from the recap of the study. First, the effects of the depression amplifiers only held true for the children who were abused and neglected. Second, children with stro

There are 3 PhD positions open at the JM Rendel laboratories, Rockhampton in the Division of Livestock Industries, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia....

This is Daddy Cat.Daddy Cat is a big guy. Just from struggling to pick him up, I'm guessing he weighs a good 30lbs. I'll let you know for sure as soon as I remember to borrow my mom's scale. Daddy Cat spends most the time on my front porch, although he would *much* rather be a housecat. See, Daddy Cat just loves to snuggle and purr and get as close to me as he possibly can. Unfortunately, there are quite a few downfalls to having Daddy Cat in the house. The biggest problem is this monster's appetite. As a multiple cat owner, I have discovered that when you have a bunch of felines running about, having multiple food bowls around the house, continuously full of dry food, is a good thing. However, while the other cats simply eat their fill, Daddy Cat will plant himself at one bowl and eat it dry; then he'll move on to the next. When Daddy Cat's inside, I have to hide the food bowls. Most of the cats residing in and around my house are incredibly friendly, both with me and with each

The prevalence of genetic disease in dogs today can only be described as alarmingly common which is bad news for dog owners and dog lovers alike. The following is a list to illustrate the magnitude of the problem:1. On average all dogs carry at least 4-5 defective genes.2. Over 500 genetic diseases have been identified in dogs.3. Hip Dysplasia (HD) (an inherited orthopedic disease that may result in the dog becoming lame) commonly occurs in 60 dog breeds and occurs less frequently in another 110 breeds; thus this disease is seen in over 170 breeds of dog.4. 119 dog breeds are commonly afflicted with progressive retinal atrophy (PRA), a disease that quite often leads to blindness in the affected animal.5. Of all the dog breeds the Poodle suffers from the most number of genetic diseases...145! The reason why the Poodle is predisposed to so many genetic diseases is because not only are there 3 distinct sizes of Poodle in this breed, the large count of disease is a reflection of the popula

A boy with Duchenne muscular dystrophy (DMD) was born to parents with no family history of the disease. The most likely explanation for this occurrence is A. a CGG expansion that resulted in the disruption of the promoter of the dystrophin geneB. infidelityC. a point mutation in the dystrophin geneD. a recombination event in the dystrophin gene that gave rise to a frameshift mutation leading to an untranslatable mRNAE. a translocation that resulted in the disruption of the dystrophin geneAnswer

Various postdoctoral research positions in molecular genetics are available in the Aquaculture Division, Department of Genetics, Stellenbosch University with the project title Genetic improvement of...

Genetic testing can be used to help personalize the therapeutic dosage of warfarin, a commonly-used anticoagulant, according to research published in the September 1, 2007, issue of Blood, the journal of the American Society of Hematology. This result represents one of the first applications of using an individual's genetic information to guide personal medical care.Because individuals metabolize drugs differently, varying doses of warfarin are needed for the drug to be effective in each patient. Too much warfarin can cause severe bleeding, and too little can cause dangerous blood clots. Currently, there is little guidance for predicting how much of the drug a person will need. Physicians have had to roughly estimate an initial dose of warfarin and then continually monitor a patient's International Normalized Ratio (INR) value (a measure of how fast the blood clots), during treatment to tweak the dosage by trial and error.For the first time, a group of St. Louis researchers combined

A 20-year-old develops weakness accompanied by difficulty in relaxation that is most pronounced in the hands and feet. Muscle biopsy demonstrates prominent ring fibers, centrally located nuclei, chains of nuclei, and disorganized sarcoplasmic masses. This condition been associated with a mutation on which of the following chromosomes?A. XB. YC. 4D. 5E. 19Answer

(Nuffield Council on Bioethics) Contents: Section I: Introduction and context Chapter 1: Introduction • Why this Working Party is important • Defining the normal range of behavioural characteristics • The scope of research in behavioural genetics • The structure of the Report Chapter 2: The historical context • The impact of eugenic thought on research into human behaviour • Conclusion Section II: Scientific background Chapter 3: Research in behavioural genetics • Introduction • What is genetic variation? • What is meant by normal variation in human behaviour? • ‘A gene for X’? • Describing human behaviour • Predicting human behaviour from genetic information • Conclusion Chapter 4: Quantitative genetics: measuring heritability • Introduction • How is population variation examined using genetic studies? • Family, twin and adoption studies • Adoption studies • Current uses of quantitative genetic studies • Conclusion Chapter 5: Identifying genet

On the first single off of his third solo album, head Black Eyed Peas genius Will.I.Am brings on the multi-hook goodness. “I Got It From My Mama” was created on the sure-fire Will.I.Am superhit formula of sub-ground, solo electricism that leans towards an extremely annoying commercial base. But hell, it worked with “My Humps”, however “I Got It…” never really leaves off the ground nor does it turn into the irresistible guilty pleasure “My Humps” and “Lets Get Retarded” became. Download | I Got It From My Mama (Genetics)

On the first single off of his third solo album, head Black Eyed Peas genius Will.I.Am brings on the multi-hook goodness. “I Got It From My Mama” was created on the sure-fire Will.I.Am superhit formula of sub-ground, solo electricism that leans towards an extremely annoying commercial base. But hell, it worked with “My Humps”, however “I Got It…” never really leaves off the ground nor does it turn into the irresistible guilty pleasure “My Humps” and “Lets Get Retarded” became. Download | I Got It From My Mama (Genetics)

This Is Rumoured To Be The Debut Solo Single From Hip-Hop Super Producer "Will.i.am".Fresh from working with the likes of "Michael Jackson" as well as working on new material for "The Black Eyed Peas", Will is finalising his own album. From day one, he has obviously been the brains behind the BEP, it's great to finally hear some solo material.Still, it is hard to hear the difference between a Peas track & this one, "I Got It From My Mama" sounds quite a bit like "My Humps", it even features female vocals that sound suspiciously like "Fergie". This is an obvious first single & very radio ready, I hope that his solo album, "Songs About Girls", produces something more innovative, which he is blatantly capable of making.LISTEN: "Will.i.am - I Got It From My Mama (Genetics)"Will.i.am,Hot Or Not?

Will.I.Am - I Got It From My Mama (Genetics)With Fergie's big solo success it's time for another BEP member to shine. That's right Will.I.Am has been busy working on his new solo album "Songs About Girls" due out September 25th!! Here we have the first single I Got It From My Mama (Genetics). The beat & melody have a nice diffrent sound to it, but it's deff a uptempo track. It's a cacthy song but I wouldn't say it's something you wouldn't expect from him. Either way I'm sure they will be playing this much on the radio. Check it out!!DL: Will.I.Am - I Got It From My Mama (Genetics)DL Link 2: HERE(Credit: Kevipod, THANKS ARE APPRECIATED)

This week a study was published about the finding of one central London Hospital A&E department, St. Thomas'. In brief they have found an increase in alcohol related problem in the early hours of the morning. This change has happened, apparently, since a change in the UK licensing laws.A government spokesperson was quick to point out that this was just the experience of one hospital. I think it was the BMA who then countered with words to the effect: "Yes, exactly - so we need more research". I suspect various government department don't want to know the answer because they have not been enthusiastic about asking the question (in terms of more research). A very informal piece of research by the BBC at an outer London hospital tended to support the St. Thomas' finding.A spokesperson for the drinks industry was quick to dismiss any link between their industry and alcohol related problem, pointing out that the supermarkets were to blame. There does seem to be evidence that peopl

Gluten sensitivity is very common, much more common than celiac disease. However, both celiac disease and gluten sensitivity are often missed, ignored or misdiagnosed. It is widely accepted celiac disease affects approximately 1% of people worldwide. It is commonly accepted that between 3-4% of people previously diagnosed with irritable bowel syndrome (IBS) have undiagnosed celiac disease. Dr’s. Rodney Ford, Ken Fine and I believe that many more than this are gluten sensitive. We believe that the presence of an elevated serum gliadin antibody is indicative of gluten sensitivity in most people. We concede that such individuals often do not have “true celiac disease” as it is now strictly defined by presence of HLA DQ2 or DQ8, a positive IgA endomysial antibody test or tissue transglutaminase IgA antibody with characteristic small bowel biopsy. However, our experience is that such individuals commonly present with symptoms identical to those with celiac disease and these sympto

EntreMetrix Inc, a business development company in California, just launched a new nutritional genomics portfolio company called K-9 Genetics Corp. This new company will develop personalized wellness programs within the ultra-premium dog food and treats industry. This includes products like Personalized Chow, Personalized Treats and all kinds of functional foods that are nutritionally balanced to meet the exact needs of each unique dog. This is the next big thing! Historically, dog food was manufactured in bulk, assuming that a single diet would fit every single dog. In the eighties dog foods were produced specific for certain dog life-stages. In the nineties more specialized dog foods were designed for different dog sizes and recently nutraceuticals are used in dog food targeted to the needs of specific dog breeds. The personalized nutrigenomics approach of K-9 Company is undoubtedly a big revolution. Nutrigenomics is the study of how an individual’s genetic makeup metabolizes

Post-Doctoral Research Associate in Statistical Genetics Genetic Epidemiology group, Department of Health Sciences, University of Leicester. Available from 1st October 2007 for 3 years (Ref: R3329) Closing Date: 3 Aug 2007 A Research Associate position is available to work on a Medical Research Council funded project on "Inferring Epidemiological Causality using Mendelian Randomisation" which is

Post-Doctoral Research Associate in Statistical Genetics Genetic Epidemiology group, Department of Health Sciences, University of Leicester. Available from 1st October 2007 for 3 years (Ref: R3329) Closing Date: 3 Aug 2007 A Research Associate position is available to work on a Medical Research Council funded project on "Inferring Epidemiological Causality using Mendelian Randomisation" which is

Can genetics explain if you are allergic to some pollens or foods? White blood cell patterns determined genetically and designated as HLA DQ and DR genes have been identified with an increased risk of pollen, dust, latex, and food allergies. The intriguing part of this story is that there is an advantage to knowing your HLA DR and DQ type when evaluating your risk for pollen allergies and their associated food allergies or cross reactions.We all have proteins on the surface of our cells that are genetically determined. These patterns are easily detectable by testing cells from blood or from the mouth. Specific patterns have been associated with increased risk for autoimmune conditions, gluten sensitivity and celiac disease. Now it appears certain DQ or DR patterns are associated with food and pollen allergies as well.Boehncke, et al. from the University of Frankfurt reported in 1998 that certain white blood cell types known HLA class II genotypes or HLA DQ and DR genetic patterns were

Genetics help decide on the teenage acne attack:  With genetics having a part in deciding the type of teenage acne you will be suffering from, it is rather difficult to avoid teenage acne if you have the gene in your body. You could only take precautions not to aggravate a teenage acne attack.  Genetics play an important part in the type of teenage acne attack you suffer from. This is the reason why some youths have only an occasional pimple or whitehead to worry about while other youths tend to have an attack that covers the whole face with blackheads, whiteheads and pimples.  Those teenagers suffering from acne attacks due to genetic factors find that it is rather difficult for them to find a cure for it. Even after trying out numerous remedies and over the counter medication, the afflicted teenagers don’t find any relief. Instead, they have their own restrictions pertaining to the food they eat, their drinks and their lifestyle.   It has been proven of the presence of a geneti

After age 65 if you are going to spend the night in the hospital, odds are it is because of heart problems. Actually, heart problems, especially heart attacks, are pretty common.Well, researchers may have stumbled on a finding which may help with recovery from heart attacks and possibly other heart problems as well. A team at Columbia University Medical Center in New York found that by switching on a gene, adult mice were able to fix the damage from a heart attack. So maybe sometime in the future when Old Joe's heart decides to take a smoke break Doc's will be able to go in, do a few molecular modifications, and help Joe's heart get back to the way it was in the good ole days.Read more for linksGene switch helps mice fix their own broken heartsAnother interesting find

Trisomy 21 may be associated with:A. Transposition of the great arteriesB. Coartation of the aortaC. Endocardial cushion defect (Arterioventricular septal defect)D. Tricuspid atresiaAnswerTags: MCQ, Genetics, down syndrome

About autosomal dominant inheritance all are true excepta.it is always expressed in homozygotesb.always one parent is affectedc.50% of children affectedd.Offspring of a nondiseased child of a diseased parent will not have the mutant gene.AnswerTags: MCQ, Genetics, Autosomal Dominant

Cats are seasonally polyestrous, which means they may have many periods of heat over the course of a year. A heat period lasts about 4 to 7 days if the female is bred; if she is not, the heat period lasts longer. The male cat’s penis has spines which point backwards. Upon withdrawal of the penis, the spines rake the walls of the female’s vagina, which may cause ovulation. Because this does not always occur, females are rarely impregnated by the first male with which they mate. Furthermore, cats are superfecund; that is, a female may mate with more than one male when she is in heat, meaning different kittens in a litter may have different fathers. The reproduction process is usually very loud, as both cats vocalize loudly. If one is not used to the sounds of cats mating, it will sound like a cat fight. The gestation period for cats is approximately 63-65 days. The size of a litter averages three to five kittens, with the first litter usually smaller than subsequent litters

Dou you know a lot about Genetics. If you don’t you should read more. Quite a hot topic since recently. Today we meet with Hsien.Dr. Hsien-Hsien Lei (http://www.aheartylife.com/?p=3), PhD is a famous Editor at b5media.com Science and Health section - look GeneticsAndHealth.com (http://geneticsandhealth.com/), AHeartyLife.com (http://www.aheartylife.com/). Also check about Family and Relationships - PlayLibrary.com She had very interesting life story, and today she kindly shares her experience with you. Please read the interview:

Scientists have made a breakthrough in their understanding of the genetics behind human eye colour. They found that just a few 'letters' out of the six billion that make up the genetic code are responsible for most of the variation in human eye colour. The research, by a team of scientists from Queensland, Australia, will appear in a forthcoming issue of the American Journal of Human Genetics. The findings are based on a genetic study of nearly 4,000 individuals. 'One of the changes is like switching the light on and off, while the other is like changing the light bulb from brown to green' - Richard Sturm* (info), University of Queensland. Differences in eye colour are largely down to 'single nucleotide polymorphisms' (SNPs - pronounced 'snips'); variations in the sequence of letters that make up a single strand of human DNA. SNPs represent a change of just one letter in the genetic sequence. These changes, or mutations, in our DNA can have important consequences for how the ge

Scientific studies of why foods such as Brussels sprouts and stout beer are horribly bitter-tasting to some people but palatable to others are shedding light on a number of questions, from the mechanisms of natural selection to understanding how our genes affect our dietary habits (see "Origins and Evolution of Human Diet").Dr. Stephen Wooding, a population geneticist at UT Southwestern Medical Center in Dallas, studies how slight variations in genes give rise to variations in traits among a given human population.Part of Dr. Wooding's research focuses on variations in the genes responsible for bitter-taste receptors, tiny receptacles on the tongue that intercept harsh-tasting chemicals from food. Each of these genes comes in several forms, and the forms you carry help determine how you perceive bitter-tasting compounds.The ability to taste or not taste bitter foods might have played a role in human evolution and may today account for such health-related behaviors as smoking and veget

The CFTR abnormality is most likely to be associated with:MalabsorptionCongenital absence of the vas deferensAzospermiaBronchiectasisRecurrent chest infectionsAnswerTags: MCQ, Genetics, Cystic Fibrosis, CFTR

Which is the gene mutation least likely to result in haemochromatosis? Heterozygous his (H63D) Heterozygous cys (C282Y) Combined his (H63D) & cys (C282Y) Homozygous cys Homozygous hisAnswerTags: MCQ, Genetics, Hemochromatosis

DVT in a 40 year old woman. Which is the most likely cause?Factor V Leiden Protein C deficiency Protein S deficiency Antithrombin III deficiency Lupus anticoagulantAnswerTags: MCQ, Genetics, DVT

A 45 year old man has Duke’s C adenocarcinoma of the colon. There is a strong family history of colon cancer in the absence of polyps. What is the most likely genetic basis?A.Mismatch repair genes B.Ras C.Deletion in colon cancer D.P glycoprotein gene E.APC geneAnswer Tags: MCQ, Genetics, adenocarcinoma, polyps

Although type 2 diabetes is strongly inherited, the nature of the genetic defect remains unknown in most cases. In those cases where the responsible mutation has been identified, it most frequently involves the gene encoding which one of the following? InsulinInsulin ReceptorGlucose transporterGlucokinaseGlycogen SynthetaseAnswerTags: MCQ, Genetics, Diabetes

Which of the following is most suggestive of a mitochondrial DNA defect as the cause of a genetic disease?A.Autosomal pattern of transmissionB.Maternal pattern of transmissionC.The finding of a cardiomyopathyD.A change in the mitochondrial DNA sequenceE.The presence of somatic mosiacismAnswerTags: MCQ, Genetics, Mitochondria

Mutations in which of the following genes when inherited in the germline are least likely to be associated with the development of breast cancer?A. ATM geneB. bcl-2 geneC. BRCA 1 geneD. BRCA 2 geneE. p53 geneAnswerTags: MCQ, Genetics, Breast Cancer